Advertisement
Healthy Aging · Circulation

The Nobel-Winning Molecule That Tells Your Blood Vessels to Relax — And Why Your Body Makes Less of It After 40

Most people over 50 have never heard of nitric oxide. Yet it helps your blood vessels relax — and that may be connected to how warm, energetic and capable you feel every day.

Healthy circulation is part of what helps everyday movement feel easier.

It starts with little things. The stairs that used to be nothing now leave you a bit winded at the top. Your hands and feet feel cold in bed, even under the blankets.

And around 3 p.m., a heaviness settles in that coffee doesn't quite fix.

You tell yourself it's just age. Maybe it is. But researchers have spent decades studying one small, overlooked molecule that plays a central role in how your blood vessels behave — and how well blood moves through your body.

It's called nitric oxide. And chances are, no one has ever mentioned it to you.

A discovery worthy of the Nobel Prize

Dr. Robert Furchgott receives the 1998 Nobel Prize in Physiology or Medicine in Stockholm.

In 1998, the Nobel Prize in Physiology or Medicine went to three American scientists — Robert Furchgott, Louis Ignarro and Ferid Murad — for discovering that nitric oxide acts as a signaling molecule in the cardiovascular system. [1]

Put simply: nitric oxide is a messenger. It's produced in the thin lining of your blood vessels, and it tells the muscle in the vessel walls to relax.

When vessels relax, they widen. And wider, more flexible vessels make it easier for blood to flow where your body needs it.

The hidden cause no one talks about

Younger vesselFlexible wall, wide open channel
Aging vessel, less nitric oxideTense wall, narrower, cramped channel

Here's what most people don't realize: your body's ability to make nitric oxide doesn't stay constant.

In a study published in the journal Hypertension, researchers found that the body's nitric oxide system begins to falter early in adulthood, and oxidative stress later compounds the problem — together driving the age-related decline in how well blood vessels relax. [2]

A landmark study of 238 healthy adults found blood vessel function declines progressively with age — starting around the 40s in men, and dropping steeply in women around menopause. [3]

It happens quietly. There's no single moment you notice it. Which may be why so many people simply chalk the changes up to "getting older."

Why it matters day to day

Healthy blood flow is how oxygen and nutrients reach your muscles, hands, feet and brain. Nitric oxide is one of the body's key tools for supporting it.

Circulation
Relaxed vessels support healthy blood flow throughout the body.†
Healthy blood pressure
Relaxed, flexible vessels are part of maintaining blood pressure already within a healthy range.†
Everyday energy
Oxygen and nutrients reach working muscles more readily.†
Supports erection firmness
Healthy blood flow is essential to normal erection firmness in men.†

Two ways your body makes nitric oxide

Your body has two main routes for producing nitric oxide. Understanding both explains a lot.

Pathway 1 · Your body's own
This is the one that slows with age
The L-arginine pathway
L-citrulline L-arginine Nitric oxide
Cells in your vessel lining use an enzyme called eNOS to turn the amino acid L-arginine into nitric oxide. Your body can also convert L-citrulline into L-arginine, helping keep this pathway supplied.
Pathway 2 · From your plate
Dietary nitrate
Nitrate → nitrite → nitric oxide
Leafy greens and beets supply natural nitrate, a second route to nitric oxide. One more reason to eat your vegetables.
Inside a blood vessel
What nitric oxide does to your blood vessels
Before Low nitric oxide
  • Vessel walls stay tense and tight
  • A narrower channel for blood to pass through
  • Blood cells squeeze through in single file
After Nitric oxide signals the walls to relax
  • Nitric oxide tells the muscle in the walls to relax
  • The vessel widens
  • Blood moves through more freely
Red blood cell Nitric oxide signal Vessel wall muscle
Simplified illustration of how nitric oxide works in the body. Not drawn to scale, and not a depiction of results from any product.

Why arginine and citrulline?

Taddei et al. · Hypertension, 2001

Nitric oxide availability declines with age, as the body's nitric oxide system falters and oxidative stress builds over time.

Celermajer et al. · J Am Coll Cardiol, 1994

Blood vessel function declines progressively with age, even in healthy adults.

Schwedhelm et al. · Br J Clin Pharmacol, 2008

Oral L-arginine is heavily broken down in the gut before it reaches the bloodstream. L-citrulline is readily absorbed and converted into L-arginine in the body. This is why many formulas pair the two.

These studies explain the science of nitric oxide and are not studies of Nitric Oxide Flow.

So what can you actually do?

Eat your greens and beets — that's the easy part of Pathway 2.

But Pathway 1, your body's own L-arginine route, is the one that tends to slow with age. Supporting it every day means giving your body the amino acids it uses to make nitric oxide.

That's exactly the idea behind a supplement from Nature's Pure Blend.

Introducing

Nitric Oxide Flow

A simple daily serving that gives your body L-arginine and L-citrulline — the building blocks of its own nitric oxide pathway.†

  • Supports nitric oxide production†
  • Supports healthy blood pressure†
  • Supports healthy circulation and blood flow†
  • Supports male bedroom performance†
  • 2 capsules daily · 30-day supply
Try Risk-Free → 30-day money-back guarantee

Two amino acids, working at both ends of your nitric oxide pathway

Per 2-capsule serving · 30 servings per container

L-Arginine
L-Arginine500 mg
L-arginine alpha-ketoglutarate: arginine bound to alpha-ketoglutarate. The amino acid your vessel lining uses directly to make nitric oxide.†
L-Citrulline
L-Citrulline250 mg
Found naturally in watermelon. The body converts it into L-arginine, helping keep the pathway supplied.†
L-Arginine HCl
L-Arginine HCl500 mg
A stable, well-absorbed form of L-arginine.†
L-Citrulline Malate
L-Citrulline Malate250 mg
L-citrulline paired with malic acid. Supports blood flow during exercise.†
GMP-certified facility
Third-party tested
Made in USA
Veggie capsules

What customers are saying

Verified Buyer
“My blood pressure has been in the normal range since I started taking the Nitric Oxide Flow.”
J James S.
Verified Buyer
“I feel calmer since starting the Flow. My BP is only down a few points but it’s better than it was”
A Anjakos A.
Verified Buyer
“Rescued me from a blood pressure Rx with horrible side effects. I’ve taken it for 3 years and wouldn’t trust my health and wellness to anyone else.”
S Steven M.

Individual results vary. Reviews reflect individual customer experiences.

Real results

Before Before
After After
“These numbers are just unprecedented. I've never been able to present numbers like those… I'm just amazed that I can get these numbers.”David B.
Before Before
After After
“Very happy with my experience using this product.”Andre S.

Results may vary.

Ready to give your body's nitric oxide pathway daily support?†

Try Risk-Free Today →

Frequently asked questions

Tap a question to see the answer.

What does Nitric Oxide Flow do?

Nitric Oxide Flow uses ingredients inspired by nature, designed to support nitric oxide production and healthy circulation and blood flow.†

How do I take Nitric Oxide Flow?

We recommend taking 2 capsules per day with a meal, and taking Nitric Oxide Flow consistently for at least 14 days.

How long does it take to see results?

Everyone is different. We recommend taking it for at least 15 days to decide if Nitric Oxide Flow is working for you. Customers tend to see better results when they also include a healthy diet, exercise and rest.†

Is Nitric Oxide Flow vegan?

Yes. Nitric Oxide Flow is 100% vegan-friendly, including the veggie capsule that holds all of the ingredients.

Is Nitric Oxide Flow dairy-free?

Yes, Nitric Oxide Flow is 100% dairy-free, although it may be processed in a facility that also handles dairy products.

Is it safe with my medications?

Please talk with your doctor before starting any supplement — especially if you take blood pressure medication, nitrates (such as nitroglycerin), or medication for erectile dysfunction, or if you are pregnant, nursing or managing a medical condition. Nitric Oxide Flow is not a replacement for any medication.

What if it doesn't work for me?

You're covered by our 30-day money-back guarantee. No questions asked.

Give your body's nitric oxide pathway daily support†

L-arginine and L-citrulline in a simple 2-capsule daily serving, backed by our 30-day money-back guarantee.

Claim my supply →

P.S. Nitric oxide helps your blood vessels relax — a discovery that earned the 1998 Nobel Prize. Your body's own production tends to slow with age. Nitric Oxide Flow gives that pathway the L-arginine and L-citrulline it runs on, every day.† And with a 30-day money-back guarantee, the only way to know how it fits your life is to try it risk-free.